latent TB infection
Clinical teaching and practical ideas for your next study session.
Medical Education
A Negative IGRA Before Biologic Therapy: When to Reopen the TB Workup
A negative IGRA before biologic or other immunosuppressive therapy lowers the probability of TB infection, but its reassurance depends on exposure timing, immune competence, and the clinical evaluation for TB disease. Learn when to repeat testing, consider a second test, or investigate further.